Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.

doi:10.1038/srep34690

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Article

Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis.

Scientific reports - 4 Oct 2016

Tanigawa Hiroki, Miyata Keishi, Tian Zhe, Aoi Jun, Kadomatsu Tsuyoshi, Fukushima Satoshi, Ogata Aki, Takeda Naoki, Zhao Jiabin, Zhu Shunshun, Terada Kazutoyo, Endo Motoyoshi, Morinaga Jun, Sugizaki Taichi, Sato Michio, Morioka Masaki Suimye, Manabe Ichiro, Mashimo Youichi, Hata Akira, Taketomi Yoshitaka, Yamamoto Kei, Murakami Makoto, Araki Kimi, Jinnin Masatoshi, Ihn Hironobu, Oike Yuichi

Abstract excerpt

Psoriasis is a chronic inflammatory skin disease marked by aberrant tissue repair. Mutant mice modeling psoriasis skin characteristics have provided useful information relevant to molecular mechanisms and could serve to evaluate therapeutic strategies. Here, we found that epidermal ANGPTL6 expression was markedly induced during tissue repair in mice. Analysis of mice overexpressing ANGPTL6 in keratinocytes...

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Identifiers

PMID: 27698489
DOI: 10.1038/srep34690
PMCID: PMC5048131

Genes

ANGPTL6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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