Article
Effect of the substitutions in the alpha helix and the beta sheet of HLA class I molecule on allorecognition of T cells specific for HLA-B51 and HLA-Bw53.
Human immunology - 1 Feb 1992
Hiraiwa M, Nishimura I, Kato N, Nagao T, Kano K, Takiguchi M
Abstract excerpt
HLA-B51 and HLA-Bw53 differ by eight amino acids on the alpha 2 domain. Of these eight amino acid substitutions, two are in the alpha helix and six are in the beta sheet. The effect of these substitutions on allorecognition of HLA-B51-specific cytotoxic T lymphocyte (CTL) clones and HLA-Bw53-spec...
Topics
- Amino Acid Sequence
- Cell Line
- Epitopes
- HLA Antigens
- HLA-B Antigens
- HLA-B51 Antigen
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Recombinant Fusion Proteins
- T-Lymphocytes, Cytotoxic