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Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways

1 Jan 2006

Abstract excerpt

Complex cellular networks regulate regeneration, detoxification and differentiation of hepatocytes. By combining experimental data with mathematical modelling, systems biology holds great promises to elucidate the key regulatory mechanisms involved and predict targets for efficient intervention. For the generation of high-quality quantitative data suitable for mathematical modelling a standardised in vitro system...

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PMID: 17186705
DOI: 10.1049/ip-syb:20050067

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