Article
P0 promoter directs expression of reporter and toxin genes to Schwann cells of transgenic mice.
Neuron - 1 Mar 1992
Messing A, Behringer R R, Hammang J P, Palmiter R D, Brinster R L, Lemke G
Abstract excerpt
We generated transgenic mice that specifically express foreign genes in myelinating Schwann cells. A 1.1 kb segment of 5' flanking sequence from the rat P0 gene was used to drive expression of the genes encoding human growth hormone (hGH) and bacterial diphtheria toxin A chain (DT-A). The P0-hGH...
Topics
- Age Factors
- Animals
- Cell Division
- Demyelinating Diseases
- Diphtheria Toxin
- Gene Expression Regulation
- Growth Hormone
- Mice
- Mice, Transgenic
- Myelin P0 Protein
- Myelin Proteins
- Peripheral Nerves
- Peripheral Nervous System Diseases
- Phenotype
- Promoter Regions, Genetic
- RNA, Messenger
- Schwann Cells