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Article

Transgenic over-expression of galanin in injured primary sensory neurons.

Neuroreport - 15 Nov 2002

Bacon Andrea, Holmes Fiona E, Small Caroline J, Ghatei Mohammed, Mahoney Sally, Bloom Stephen, Wynick David

Abstract excerpt

The 29 amino acid neuropeptide galanin is normally expressed in < 5% of sensory neurons in the adult dorsal root ganglia. After nerve transection (axotomy), the galanin content of the dorsal root ganglia rises 120-fold and the peptide is then expressed in > 50% of neurons. Published data suggest...

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Source

Identifiers

PMID: 12438940
DOI: 10.1097/00001756-200211150-00028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12438940-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Transgenic over-expression of galanin in injured primary sensory neurons.PMID 12438940Read ↗

Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice.Semantic proximity Read ↗

Generation and phenotypic characterization of a galanin overexpressing mouse.Semantic proximity Read ↗

Characterization of an enhancer region of the galanin gene that directs expression to the dorsal root ganglion and confers responsiveness to axotomy.Semantic proximity Read ↗

Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour.Semantic proximity Read ↗

The role of galanin as a multi-functional neuropeptide in the nervous system.Semantic proximity Read ↗

Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse--possible implications for pain processing.Semantic proximity Read ↗

Immunohistochemical phenotype of sensory neurons associated with sympathetic plexuses in the trigeminal ganglia of adult nerve growth factor transgenic mice.Semantic proximity Read ↗

Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain-like behaviour.Semantic proximity Read ↗

Galaninergic mechanisms at the spinal level: focus on histochemical phenotyping.Semantic proximity Read ↗

Galanin overexpressing transgenic mice.Semantic proximity Read ↗

Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivoSemantic proximity Read ↗

Genotype-selective phenotypic switch in primary afferent neurons contributes to neuropathic pain.Semantic proximity Read ↗

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