Article
Rodent UV-sensitive mutant cell lines in complementation groups 6-10 have normal general excision repair activity.
Nucleic acids research - 1 Mar 1997
Reardon J T, Thompson L H, Sancar A
Abstract excerpt
Mammalian nucleotide excision repair is the primary enzymatic pathway for removing bulky lesions from DNA. The repair reaction involves three main steps: (i) dual incisions on both sides of the lesion; (ii) excision of the damaged base in an oligonucleotide 24-31 nt in length; (iii) filling in of the post-excision gap and ligation. We have developed assays that probe the individual steps of the reaction. Using...
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