Article
Phenotypic heterogeneity in nucleotide excision repair mutants of rodent complementation groups 1 and 4.
Mutation research - 12 Mar 1997
Busch D B, van Vuuren H, de Wit J, Collins A, Zdzienicka M Z, Mitchell D L, Brookman K W, Stefanini M, Riboni R, Thompson L H, Albert R B, van Gool A J, Hoeijmakers J
Abstract excerpt
Rodent ultraviolet light (UV)-sensitive mutant cells in complementation groups (CGs) 1 and 4 normally are known for their extraordinary (approximately 80-100 x) sensitivity to mitomycin C (MMC), although some CG1 mutants with reduced MMC sensitivity were previously reported (Stefanini et al. (1987) Cytotechnology 1, 91). We report here new CG1 and CG4 mutants with only 1.6-10 x wild-type MMC sensitivity despite...
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