Mechanisms of multidrug resistance in human tumor cells. The roles of P-glycoprotein, DNA topoisomerase II, and other factors.

doi:10.1016/0305-7372(90)90011-4

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Article

Mechanisms of multidrug resistance in human tumor cells. The roles of P-glycoprotein, DNA topoisomerase II, and other factors.

Cancer treatment reviews - 1 Dec 1990

Beck W T

Abstract excerpt

Multidrug resistance (MDR) associated with overexpression of P-glycoprotein (Pgp) is a well-described experimental phenomenon that appears to have clinical correlates. However, recent descriptions of non-P-glycoprotein forms of MDR have complicated efforts to detect and circumvent MDR in the tumo...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
DNA Topoisomerases, Type II
Drug Resistance
Glutathione
Humans
Membrane Glycoproteins
Phenotype
Tumor Cells, Cultured

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