Article
Heterogeneity of linear B cell epitopes of the measles virus fusion protein reacting with late convalescent sera.
The Journal of general virology - 1 Sept 1992
Wiesmüller K H, Spahn G, Handtmann D, Schneider F, Jung G, Muller C P
Abstract excerpt
B cell epitopes of the measles virus fusion protein were mapped, by reacting sera from late convalescent donors with synthetic overlapping pentadecapeptides, segments covering the whole F protein sequence. Unselected individual sera recognized 7 to 20% of the total sequence. Cumulation of the binding patterns of 30 sera identified eight to 10 clusters of antibody-binding peptides spread over most of the sequence....
Topics
- Adult
- Amino Acid Sequence
- Antibodies, Viral
- B-Lymphocytes
- Base Sequence
- Convalescence
- Epitopes
- Genetic Variation
- Humans
- Measles virus
- Molecular Sequence Data