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Article

Changes in conserved region 3 of Escherichia coli sigma 70 mediate ppGpp-dependent functions in vivo.

Journal of molecular biology - 6 Oct 1995

Hernandez V J, Cashel M

Abstract excerpt

In Escherichia coli, deletion of relA and spoT results in an inability to synthesize ppGpp, guanosine-3',5'-bis(pyrophosphate), and a loss in the ability to grow on amino acid-free minimal media. Two spontaneous missense suppressor alleles, rpoD(P504L) and rpoD(S506F), able to confer complete prototrophy without the reappearance of ppGpp, were localized to that portion of rpoD coding for conserved region 3.1 of...

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Identifiers

PMID: 7563072
DOI: 10.1006/jmbi.1995.0518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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