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Article

The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis.

Journal of bacteriology - 1 Apr 2009

Abranches Jacqueline, Martinez Alaina R, Kajfasz Jessica K, Chávez Violeta, Garsin Danielle A, Lemos José A

Abstract excerpt

The stringent response is a global bacterial response to stress that is mediated by accumulation of the alarmone (p)ppGpp. In this study, treatment with mupirocin was shown to induce high levels of (p)ppGpp production in Enterococcus faecalis, indicating that this nosocomial pathogen can mount a classic stringent response. In addition, (p)ppGpp was found to accumulate in cells subjected to heat shock, alkaline...

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Identifiers

PMID: 19168608
DOI: 10.1128/JB.01726-08
PMCID: PMC2655485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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