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Article

The effects of cysteine mutations on the reverse transcriptases of human immunodeficiency virus types 1 and 2.

The Journal of biological chemistry - 15 Jan 1992

Hizi A, Shaharabany M, Tal R, Hughes S H

Abstract excerpt

Chemical modification of HIV-1 and HIV-2 (human immunodeficiency virus, types 1 and 2) reverse transcriptases (RT) with three thiol reactive compounds selectively inhibits the RNase H function of the enzyme. HIV-1 RT has 2 cysteines (at positions 38 and 280); HIV-2 RT has 3 (38, 280, 445). Both of the cysteines in HIV-1 RT are in the polymerase domain. To investigate the role of the cysteines in the structure and...

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PMID: 1370463

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