Article
Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy - 1 Jul 1995
Boyer P L, Hughes S H
Abstract excerpt
We have analyzed recombinant human immunodeficiency virus type 1 reverse transcriptases that contain mutations at position 184. These variants retain high levels of RNA-dependent DNA polymerase activity and show resistance to ddITP. However, the mutants varied in their ability to polymerize proce...
Topics
- Base Sequence
- Binding Sites
- DNA Mutational Analysis
- DNA-Directed DNA Polymerase
- Escherichia coli
- HIV Reverse Transcriptase
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- RNA-Directed DNA Polymerase
- Recombinant Proteins