Structural analysis of human immunodeficiency virus type 1 Gag protein interactions, using cysteine-specific reagents.

doi:10.1128/JVI.70.8.5106-5114.1996

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Article

Structural analysis of human immunodeficiency virus type 1 Gag protein interactions, using cysteine-specific reagents.

Journal of virology - 1 Aug 1996

McDermott J, Farrell L, Ross R, Barklis E

Abstract excerpt

We have examined structural interactions of Gag proteins in human immunodeficiency virus type 1 (HIV-1) particles by utilizing cysteine mutagenesis and cysteine-specific modifying reagents. In immature protease-minus but otherwise wild-type (wt) particles, precursor Pr55Gag proteins did not form...

Topics

Animals
Cells, Cultured
Cricetinae
Cysteine
DNA, Recombinant
Gene Products, gag
HIV-1
Humans
Mutagenesis, Site-Directed
Mutation

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