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Article

Age-associated increase in number of CD4+CD8+ intestinal intraepithelial lymphocytes in rats.

European journal of immunology - 1 Jan 1992

Takimoto H, Nakamura T, Takeuchi M, Sumi Y, Tanaka T, Nomoto K, Yoshikai Y

Abstract excerpt

A significant number of CD4+CD8+ T cells were detected in intestinal intraepithelial lymphocytes (IEL) of various strains of rats including Wistar, WKA, BN, LEW and F344. The site of the CD4+CD8+ population in IEL increased with age in all strains we examined. Most IEL bearing CD8 expressed no CD5 antigen in young rats, while all CD4+CD8+ IEL and some of CD8+ IEL in aged rats were of CD5+CD45RB- phenotype. In...

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PMID: 1370412
DOI: 10.1002/eji.1830220124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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