Article
Zic2 patterns binocular vision by specifying the uncrossed retinal projection.
Cell - 5 Sept 2003
Herrera Eloísa, Brown Lucia, Aruga Jun, Rachel Rivka A, Dolen Gül, Mikoshiba Katsuhiko, Brown Stephen, Mason Carol A
Abstract excerpt
During CNS development, combinatorial expression of transcription factors controls neuronal subtype identity and subsequent axonal trajectory. Regulatory genes designating the routing of retinal ganglion cell (RGC) axons at the optic chiasm to the appropriate hemisphere, a pattern critical for proper binocular vision, have not been identified. Here, we show that the zinc finger transcription factor Zic2, a...
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