Article
Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects.
Genesis (New York, N.Y. : 2000) - 1 May 2000
Rachel R A, Murdoch J N, Beermann F, Copp A J, Mason C A
Abstract excerpt
In a new mouse mutant, circletail (Crc), failure of neural tube closure (embryonic day [E] 8-9) is associated with errors in retinal axon projection at the optic chiasm (E12-18), such that many axons normally projecting contralaterally instead grow to ipsilateral targets. Although the architecture of the chiasmatic region is altered, neurons and glia containing putative cues for axon guidance are present. The...
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