Article
Association of CYP2E1 gene polymorphism with predisposition to cancer development.
Experimental oncology - 1 Dec 2005
Danko I M, Chaschin N A
Abstract excerpt
We summarize research results on association of cytochrome P450 2E1 (CYP2E1) genetic polymorphisms with the development of ecologically determined cancers. Cytochrome P450 monooxygenase enzyme system is involved in metabolic activation of procarcinogens, which is an important stage during normal cell transformation into a malignant one. Studies of association between CYP2E1 gene polymorphisms and the risk of...
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