Article
[An analysis of the ionic regulation of the specific binding of 3H-diazepam depending on the phenotype of the emotional stress reaction].
Biulleten' eksperimental'noi biologii i meditsiny - 1 Nov 1992
Seredenin S B, Blednov Iu A, Nagovitsina Iu A
Abstract excerpt
It was shown that low NaCl concentrations (less than 50 mM) had more pronounced stimulatory effect on [3H]-diazepam ([3H]-DZ) binding in brain membranes of Balb/c (C) mice than in C57B1/6 (B6) mice. These interstrain differences disappeared after emotional stress in "open field" (OF) test. Low doses of diazepam (0.75 mg/kg) and hydazepam (1 mg/kg) induced anxiolytic effect in C mice and restored their normal...
Topics
- Animals
- Anti-Anxiety Agents
- Benzodiazepines
- Benzodiazepinones
- Brain
- Diazepam
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Phenotype