Article
[The anxiolytic action of an analog of the endogenous peptide tuftsin on inbred mice with different phenotypes of the emotional stress reaction].
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova - 1 Jan 2000
Seredenin S B, Kozlovskaia M M, Blednov Iu A, Kozlovskiĭ I I, Semenova T P, Czabak-Garbacz R, Nezavibat'ko V N, Miasoedov N F
Abstract excerpt
The anxiolytic effect of the synthetic analogue of the endogenous peptide tuftsin (Thr-Lys-Pro-Arg-Pro-Gly-Pro) was studied in inbred mice Balb/c (C) and C57B1/6 (B6) with different heritable types of emotional-stress reaction. In C strain with genetically high level of anxiety and "passive" type of behaviour under conditions of avoidable and unavoidable stress (open field, elevated plus-maze, light-dark chamber)...
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