Article
[The pharmacogenetic concept of the anxio-selective effect].
Vestnik Rossiiskoi akademii meditsinskikh nauk - 1 Jan 1998
Seredenin S B, Voronina T A, Neznamov G G, Blednov Iu A, Badyshtov B A, Viglinskaia I V, Kozlovskaia M M, Kolotilinskaia N V, Iarkova M A, Savel'ev V L, Garibova T L, Val'dman E A
Abstract excerpt
Hereditary variations in the effects of benzodiazepine tranquilizers depending on the phenotype of an emotional stress reaction (ESR) are described. The membrane-receptor relationship showed differences between C57B1/6 with an "active" ESR phenotype and Balb/c with a "passive" ESR at the GABA benzodiazepine receptor complex level. The pharmacological results evidenced the selective anxiolytic properties of the...
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