Article
[The effect of bromantane on the behavior of inbred mouse strains with different phenotypes of emotional stress reaction].
Eksperimental'naia i klinicheskaia farmakologiia - 1 Jan 2000
Seredenin S B, Miramedova A G, Kozlovskaia M M
Abstract excerpt
Per os administration of bromantan (2-[n-bromphenyl]-aminoadamantan) in doses of 40-50 mg/kg prevents the fixed posture reaction and reduces the level of defecation in Balb/c mice in the "open field" test and activates their behavior in the "elevated plus maze" test. It increases the motor activity of C57B1/c mice in both tests. It is concluded that an anxiolytic effect is present in the spectrum of...
Topics
- Amantadine
- Animals
- Behavior, Animal
- Dose-Response Relationship, Drug
- Male
- Maze Learning
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Phenotype
- Psychotropic Drugs
- Stress, Psychological