The impact of phenotypic variation on genetic analysis: application to X-linkage in manic-depressive illness.

doi:10.1111/j.1600-0447.1990.tb03052.x

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Article

The impact of phenotypic variation on genetic analysis: application to X-linkage in manic-depressive illness.

Acta psychiatrica Scandinavica - 1 Sept 1990

Baron M, Hamburger R, Sandkuyl L A, Risch N, Mandel B, Endicott J, Belmaker R H, Ott J

Abstract excerpt

Genetic linkage studies have opened new vistas for behavioral and psychiatric genetics. However, phenotypic diversity and diagnostic uncertainties can lead to spurious linkage findings. A method of analysis is proposed that takes these factors into account. When applied to manic-depressive disease, the results indicate that previous evidence for a major gene localized on the distal long arm of the X-chromosome...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Bipolar Disorder
Chromosome Mapping
Diagnosis, Differential
Female
Genetic Linkage
Humans
Lod Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Logistic Models

Male

Middle Aged

Pedigree

Phenotype

X Chromosome

Source

Open in PubMed

Identifiers

PMID: 2248044
DOI: 10.1111/j.1600-0447.1990.tb03052.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2248044-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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