Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction.

doi:10.1073/pnas.89.21.10065

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1992

Peinado M A, Malkhosyan S, Velazquez A, Perucho M

Abstract excerpt

The arbitrarily primed polymerase chain reaction (AP-PCR) [Welsh, J. & McClelland, M. (1990) Nucleic Acids Res. 18, 7213-7218] has been used to detect somatic genetic alterations in tumors of the colon and rectum. DNA fingerprints generated by single arbitrary primers were compared between normal and tumor tissue of the same individuals. AP-PCR bands showing decreased and increased intensities in tumor tissue...

Topics

Adenocarcinoma
Adenoma
Alleles
Base Sequence
Blotting, Southern
Chromosomes, Human, Pair 17
Colonic Neoplasms
DNA Fingerprinting
DNA, Neoplasm
Humans
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Rectal Neoplasms

Restriction Mapping

Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 1359533
DOI: 10.1073/pnas.89.21.10065
PMCID: PMC50278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1359533-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction.PMID 1359533Read ↗

Molecular karyotype (amplotype) of metastatic colorectal cancer by unbiased arbitrarily primed PCR DNA fingerprinting.Semantic proximity Read ↗

Tracking recurrent quantitative genomic alterations in colorectal cancer: allelic losses in chromosome 4 correlate with tumor aggressiveness.Semantic proximity Read ↗

Identification of allelic loss on chromosome arm 6p in human astrocytomas by arbitrarily primed polymerase chain reaction.Semantic proximity Read ↗

Detection of microsatellite instability in cancers by arbitrarily primed-PCR fingerprinting using a fluorescently labeled primer (FAP-PCR).Semantic proximity Read ↗

Genomic instability in ovarian cancer: a reassessment using an arbitrarily primed polymerase chain reaction.Semantic proximity Read ↗

Differences in patterns of allelic loss between two common types of adult cancer, breast and colon carcinoma, and Wilms' tumor of childhood.Semantic proximity Read ↗

Genetic alteration in oral squamous cell carcinoma detected by arbitrarily primed polymerase chain reaction.Semantic proximity Read ↗

Survival and acquired genetic alterations in colorectal cancer.Semantic proximity Read ↗

Nonradioactive arbitrarily primed polymerase chain reaction: a novel technique for detecting genetic defects in skin tumors.Semantic proximity Read ↗

Allele loss from chromosome 17 in ovarian cancer.Semantic proximity Read ↗

Allelic loss of the p53 gene in colorectal cancer.Semantic proximity Read ↗

High frequency of allelic deletion on chromosome 17p in advanced colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.