Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tracking recurrent quantitative genomic alterations in colorectal cancer: allelic losses in chromosome 4 correlate with tumor aggressiveness.

Laboratory investigation; a journal of technical methods and pathology - 1 Feb 1999

Arribas R, Risques R A, Gonzalez-Garcia I, Masramon L, Aiza G, Ribas M, Capellà G, Peinado M A

Abstract excerpt

Allelic imbalances are common events in cancer cells. Quantitative alterations in specific chromosomal loci have been linked to activation (gain) or inactivation (loss) of genes with a proven impact on tumor cell biology. The aim of this study was to detect new chromosomal regions recurrently altered in colorectal tumorigenesis and with a potential effect on patient's outcome. We have analyzed a series of human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 4

Share to Colorectal Neoplasms

Share to Gene Expression Regulation

Share to Genome, Human

Share to Polymerase Chain Reaction

Share to Survival Analysis

Source

Identifiers

PMID: 10068200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tracking recurrent quantitative genomic alterations in colorectal cancer: allelic losses in chromosome 4 correlate with tumor aggressiveness.PMID 10068200Read ↗

Molecular karyotype (amplotype) of metastatic colorectal cancer by unbiased arbitrarily primed PCR DNA fingerprinting.Semantic proximity Read ↗

Prospective assessment of allelic losses at 4p14-16 in colorectal cancer: two mutational patterns and a locus associated with poorer survival.Semantic proximity Read ↗

Genetic imbalances with impact on survival in colorectal cancer patientsSemantic proximity Read ↗

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction.Semantic proximity Read ↗

Characterization of genomic instability in ulcerative colitis neoplasia leads to discovery of putative tumor suppressor regions.Semantic proximity Read ↗

Impact of chromosomal instability on colorectal cancer progression and outcomeSemantic proximity Read ↗

Genome-wide allelotyping indicates increased loss of heterozygosity on 9p and 14q in early age of onset colorectal cancer.Semantic proximity Read ↗

Prognostic relevance of DNA copy number changes in colorectal cancerSemantic proximity Read ↗

Multiple regions of chromosome 4 demonstrating allelic losses in breast carcinomas.Semantic proximity Read ↗

Comparative genomic analysis of tumors: detection of DNA losses and amplification.Semantic proximity Read ↗

Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.Semantic proximity Read ↗

Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.