Article
Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor.
Human molecular genetics - 1 Feb 2003
Duan Jubao, Wainwright Mark S, Comeron Josep M, Saitou Naruya, Sanders Alan R, Gelernter Joel, Gejman Pablo V
Abstract excerpt
Although changes in nucleotide sequence affecting the composition and the structure of proteins are well known, functional changes resulting from nucleotide substitutions cannot always be inferred from simple analysis of DNA sequence. Because a strong synonymous codon usage bias in the human DRD2 gene, suggesting selection on synonymous positions, was revealed by the relative independence of the G+C content of...
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