Article
In search of genes causing spontaneous hypertension.
Clinical and experimental pharmacology & physiology - 1 Dec 1995
Nara Y, Ikeda K, Matsumoto C, Nabika T, Sawamura M, Yamori Y
Abstract excerpt
1. Basal high blood pressure (BP) in the male and female F2 progeny produced by crosses between Wistar Kyoto rats (WKY/lzm) and stroke-prone spontaneously hypertensive rats (SHRSP/lzm) linked strongly with the leukosialin locus on chromosome 1. 2. Excess salt intake caused elevation of BP and the response was larger in the females than the males. 3. In the male F2 progeny, salt-sensitive hypertension...
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