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Article

A single-base-pair substitution abolishes D-amino-acid oxidase activity in the mouse.

Biochimica et biophysica acta - 25 Aug 1992

Sasaki M, Konno R, Nishio M, Niwa A, Yasumura Y, Enami J

Abstract excerpt

Mutant ddY/DAO- mice lacking D-amino-acid oxidase (DAO) activity were examined for the cause of their lack of enzyme activity. Total RNA was extracted from the kidney of the ddY/DAO- mice and cDNA was synthesized. After cDNA encoding DAO was amplified by the polymerase chain reaction it was cloned into a plasmid and sequenced. Comparison of the DAO cDNA sequence with that of normal BALB/c mice revealed the...

Topics

Animals
Base Composition
Base Sequence
D-Amino-Acid Oxidase
DNA
Immunoblotting
Mice
Molecular Sequence Data
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1355365
DOI: 10.1016/0925-4439(92)90107-x

Genes

DAO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1355365-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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