The murine mutation jaundiced is caused by replacement of an arginine with a stop codon in the mRNA encoding the ninth repeat of beta-spectrin.

doi:10.1073/pnas.91.21.10099

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Article

The murine mutation jaundiced is caused by replacement of an arginine with a stop codon in the mRNA encoding the ninth repeat of beta-spectrin.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 1994

Bloom M L, Kaysser T M, Birkenmeier C S, Barker J E

Abstract excerpt

The jaundiced, ja/ja, mouse mutant has a severe hemolytic anemia associated with a deficiency of beta-spectrin in erythrocyte ghosts. Genes for the disease phenotype and beta-spectrin colocalize on Chromosome 12. beta-Spectrin mRNA is not detected in reticulocytes or in brain from newborn mutant...

Topics

Amino Acid Sequence
Anemia, Hemolytic
Animals
Animals, Newborn
Arginine
Base Sequence
Brain
Chromosome Mapping
Cloning, Molecular
Codon
Crosses, Genetic
DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Homozygote

Jaundice

Mice

Mice, Inbred C57BL

Mice, Inbred Strains

Source

Open in PubMed Open full text

Identifiers

PMID: 7937844
DOI: 10.1073/pnas.91.21.10099
PMCID: PMC44965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7937844-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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