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Article

Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.

Molecular pharmacology - 1 Feb 2000

Fantz C, Shaw D, Jennings W, Forsthoefel A, Kitchens M, Phan J, Minor W, Lebioda L, Berger F G, Spencer H T

Abstract excerpt

Drug-resistant variants of thymidylate synthase (TS) can potentially be used in gene therapy applications to decrease the myelosuppressive side effects of TS-directed anticancer agents or to select genetically modified cells in vivo. Mutations of proline 303 of human TS confer resistance to TS-directed fluoropyrimidines and antifolates (). We generated the corresponding variants in Escherichia coli TS (ecTS),...

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PMID: 10648646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.PMID 10648646Read ↗

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