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Article

Genetic variation in thymidylate synthase confers resistance to 5-fluorodeoxyuridine.

Advances in experimental medicine and biology - 1 Jan 1993

Hughey C T, Barbour K W, Berger F G, Berger S H

Abstract excerpt

The human colorectal tumor cell line HCT 116 was resident to the cytotoxic effects of 5-fluorodeoxyuridine (FdUrd). The response to FdUrd was increased only slightly by the presence of 10 microM folinic acid (CF). HCT 116 formed FdUMP and CH2H4PteGlu polyglutamates after exposure to FdUrd and CF. The sensitivity to FdUrd correlated well with the extent of TS inhibition. The role of TS in the resistance of the...

Topics

Colorectal Neoplasms
Drug Resistance
Floxuridine
Genetic Variation
Humans
Ligands
Thymidylate Synthase
Tumor Cells, Cultured

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8178730
DOI: 10.1007/978-1-4615-2488-5_8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8178730-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic variation in thymidylate synthase confers resistance to 5-fluorodeoxyuridine.PMID 8178730Read ↗

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