Article
CD2-mediated autocrine growth of herpes virus saimiri-transformed human T lymphocytes.
The Journal of experimental medicine - 1 Sept 1992
Mittrücker H W, Müller-Fleckenstein I, Fleckenstein B, Fleischer B
Abstract excerpt
Herpes virus saimiri (HVS) immortalizes T lymphocytes from a variety of primates and causes acute T cell lymphomas and leukemias in nonnatural primate hosts. Here we have analyzed the requirements for growth of three HVS-transformed human T cell lines. The cells expressed the phenotype of activat...
Topics
- Antigens, Differentiation, T-Lymphocyte
- CD2 Antigens
- Cell Division
- Cell Transformation, Viral
- Herpesvirus 2, Saimiriine
- Humans
- Interleukin-2
- Lymphocyte Activation
- Phenotype
- Receptors, Immunologic
- T-Lymphocytes