Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD2-mediated autocrine growth of herpes virus saimiri-transformed human T lymphocytes.

The Journal of experimental medicine - 1 Sept 1992

Mittrücker H W, Müller-Fleckenstein I, Fleckenstein B, Fleischer B

Abstract excerpt

Herpes virus saimiri (HVS) immortalizes T lymphocytes from a variety of primates and causes acute T cell lymphomas and leukemias in nonnatural primate hosts. Here we have analyzed the requirements for growth of three HVS-transformed human T cell lines. The cells expressed the phenotype of activated T cells: two were CD4+, and one was CD8+. All three cells responded to all allogeneic human cell lines tested with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to T-Lymphocytes
Share to Antigens, Differentiation, T-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Division

Share to Cell Transformation, Viral

Share to Interleukin-2

Share to Lymphocyte Activation

Share to Phenotype

Share to Receptors, Immunologic

Source

Open in PubMed Open full text

Identifiers

PMID: 1355105
DOI: 10.1084/jem.176.3.909
PMCID: PMC2119356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD2-mediated autocrine growth of herpes virus saimiri-transformed human T lymphocytes.PMID 1355105Read ↗

Herpes virus saimiri-transformed human T lymphocytes: normal functional phenotype and preserved T cell receptor signalling.Semantic proximity Read ↗

Immortalization with herpesvirus saimiri modulates the cytokine secretion profile of established Th1 and Th2 human T cell clones.Semantic proximity Read ↗

Study of Herpesvirus saimiri immortalization of gammadelta T cells derived from peripheral blood and CSF of multiple sclerosis patients.Semantic proximity Read ↗

Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes.Semantic proximity Read ↗

T-cell growth transformation by herpesvirus saimiri is independent of STAT3 activation.Semantic proximity Read ↗

Stable growth transformation of human T lymphocytes by herpesvirus saimiri.Semantic proximity Read ↗

IL-2 independent transformation of a unique human T cell line, TY8-3, and its subclones by HTLV-I and -II.Semantic proximity Read ↗

Herpesvirus saimiri transformed T cells and peripheral blood mononuclear cells restimulate identical antigen-specific human T cell clones.Semantic proximity Read ↗

Recognition and destruction of virus-infected cells by human gamma delta CTL.Semantic proximity Read ↗

Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells.Semantic proximity Read ↗

CD8-positive adult T-cell leukemia cells with an integrated defective HTLV-I genome show a paracrine growth to IL-2.Semantic proximity Read ↗

Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.