Article
Immortalization with herpesvirus saimiri modulates the cytokine secretion profile of established Th1 and Th2 human T cell clones.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1993
De Carli M, Berthold S, Fickenscher H, Fleckenstein I M, D'Elios M M, Gao Q, Biagiotti R, Giudizi M G, Kalden J R, Fleckenstein B
Abstract excerpt
T blasts of six established human CD4+ T cell clones with defined Ag specificity and cytokine secretion profile (3 Th1 and 3 Th2) were immortalized with Herpesvirus saimiri (HVS) and compared with their uninfected counterparts for their ability to proliferate, produce cytokines, and express cytolytic activity. HVS-transformed Th1 and Th2 clones neither substantially changed their original surface markers nor lose...
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