Article
Herpes virus saimiri-transformed human T lymphocytes: normal functional phenotype and preserved T cell receptor signalling.
International immunology - 1 Aug 1993
Mittrücker H W, Müller-Fleckenstein I, Fleckenstein B, Fleischer B
Abstract excerpt
Herpes virus saimiri (HVS), a primate herpes virus, transforms human CD4+ and CD8+ T lymphocytes to continuous growth in vitro. We have previously shown that HVS-transformed human T cells (HVS-T cells) respond to stimulation via CD2 with autocrine growth. In the present study we have investigated...
Topics
- Antigens
- Antigens, Differentiation, T-Lymphocyte
- CD2 Antigens
- Cell Line, Transformed
- Cell Transformation, Viral
- Herpesvirus 2, Saimiriine
- Humans
- Interleukin-2
- Lymphocyte Activation
- Phenotype
- Receptors, Antigen, T-Cell
- Receptors, Immunologic
- T-Lymphocytes