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Article

Phenotype and regulation of immunosuppressive Vδ2-expressing γδ T cells.

Cellular and molecular life sciences : CMLS - 1 May 2014

Peters Christian, Oberg Hans-Heinrich, Kabelitz Dieter, Wesch Daniela

Abstract excerpt

The proliferation and interleukin-2 production of CD4(+)CD25(-) αβ T cells were inhibited in a cell-contact manner by Vδ2 γδ T cells. The transcription factor Helios was constitutively expressed in about one-third of circulating γδ T cells and was upregulated by CD28-signaling. Our data suggest that Helios could serve as a marker for differential activation status rather than for regulatory T cells (Treg). Our...

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Identifiers

PMID: 24091816
DOI: 10.1007/s00018-013-1467-1
PMCID: PMC3997799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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