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Article

Role of HER2 gene overexpression in breast carcinoma

1 Feb 2000

Abstract excerpt

The HER2 proto-oncogene encodes a transmembrane glycoprotein of 185 kDa (p185(HER2)) with intrinsic tyrosine kinase activity. Amplification of the HER2 gene and overexpression of its product induce cell transformation. Numerous studies have demonstrated the prognostic relevance of p185(HER2), which is overexpressed in 10% to 40% of human breast tumors. Recent data suggest that p185(HER2) is a ligand orphan...

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PMID: 10623878
DOI: 10.1002/(sici)1097-4652(200002)182:2<150::aid-jcp3>3.0.co;2-e

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