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Article

Optimization of immunohistochemical detection of ERBB2 in human breast cancer: Impact of fixation

1 May 1994

Abstract excerpt

In an attempt to standardize the immunohistochemical detection of ERBB2, we evaluated six normal breast samples and 58 breast carcinomas for (1) the effect of four different fixatives (Bouin's fluid, buffered formalin, alcoholic formalin, and methacarn), and (2) the sensitivity and specificity of eight commercially available antibodies. ERBB2 gene copy numbers and RNA transcripts were measured by Southern and...

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PMID: 7931839
DOI: 10.1002/path.1711730111

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