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Article

Detection of sequence variations in the human insulin-receptor gene by parallel denaturing gradient gel electrophoresis.

Human mutation - 1 Jan 1993

Desbois C, Magré J, Blanquet V, Capeau J, Goossens M, Besmond C

Abstract excerpt

We developed a parallel denaturing gradient gel electrophoresis (DGGE) protocol to maximize the detection of nucleotide variants in the DNA sequence coding for the mature insulin receptor and in splice site junctions. The melting behaviours of exons 2 to 22 and flanking intronic sequences were computer-simulated using two programs, MELT87 and SQHTX. The data obtained from computer analysis were used to select...

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Identifiers

PMID: 8257993
DOI: 10.1002/humu.1380020512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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