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Article

Polymerase chain reaction-based genotyping for allotypic markers of immunoglobulin kappa shows allelic association of Km with kappa variable segment.

Genomics - 1 May 1992

Moxley G, Gibbs R S

Abstract excerpt

Allotypic markers of immunoglobulin kappa (Km) may be determined using a novel method of amplification of the constant segment (C kappa) (IGKC) by polymerase chain reaction (PCR) followed by restriction enzyme digestion. Restriction sites in the C kappa PCR product correlate with allotypic differences among Km(1), Km(1,2), and Km(3) alleles. An AccI site in the PCR product correlates with Km(3); and presence or...

Topics

Alleles
Arthritis, Rheumatoid
Base Sequence
Genetic Markers
Genotype
Humans
Immunoglobulin Allotypes
Immunoglobulin Constant Regions
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

White People

Source

Identifiers

PMID: 1349568
DOI: 10.1016/0888-7543(92)90208-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1349568-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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