Article
Variable-constant segment genotype of immunoglobulin kappa is associated with increased risk for rheumatoid arthritis.
Arthritis and rheumatism - 1 Jan 1992
Moxley G
Abstract excerpt
OBJECTIVE: To further investigate the association of rheumatoid arthritis (RA) with a particular genotype identified by a restriction site polymorphism near the constant segment of immunoglobulin kappa (C kappa). METHODS: The frequencies of genomic DNA polymorphisms detected within or near C kappa (the most C kappa-proximal variable segment [V kappa] B3 and a T lymphocyte marker [CD8A]) were determined by...
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