Variable-constant segment genotype of immunoglobulin kappa is associated with increased risk for rheumatoid arthritis.

doi:10.1002/art.1780350104

Back to search

Article

Variable-constant segment genotype of immunoglobulin kappa is associated with increased risk for rheumatoid arthritis.

Arthritis and rheumatism - 1 Jan 1992

Moxley G

Abstract excerpt

OBJECTIVE: To further investigate the association of rheumatoid arthritis (RA) with a particular genotype identified by a restriction site polymorphism near the constant segment of immunoglobulin kappa (C kappa). METHODS: The frequencies of genomic DNA polymorphisms detected within or near C kapp...

Topics

Alleles
Arthritis, Rheumatoid
CD8 Antigens
DNA
Gene Frequency
Genotype
HLA-DR Antigens
Haplotypes
Homozygote
Humans
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Polymorphism, Genetic
Risk Factors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.