Article
Km typing with PCR: application to population screening.
American journal of human genetics - 1 Mar 1991
Kurth J H, Bowcock A M, Erlich H A, Nevo S, Cavalli-Sforza L L
Abstract excerpt
The immunoglobulin kappa light chain (IgK) locus may play a significant role in the pathology of both infectious and autoimmune diseases. Most of the work on IgK genetics has been conducted using immunological techniques for allelic typing and sequence analysis. This is restricted by availability of reagents and can be both expensive and time-consuming. PCR primers were designed to amplify the kappa constant gene...
Topics
- Alleles
- Base Sequence
- Binding Sites
- Blood Grouping and Crossmatching
- Chromosome Mapping
- DNA
- Gene Frequency
- Genetic Testing
- Humans
- Immunoglobulin kappa-Chains
- Molecular Sequence Data