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Article

HLA-DQA11 contributes to resistance and A13 confers susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.

Diabetologia - 1 Feb 1991

Yamagata K, Hanafusa T, Nakajima H, Sada M, Amemiya H, Noguchi T, Tanaka T, Kono N, Tarui S

Abstract excerpt

In this study HLA-DQA1 and TNF genes in addition to HLA-DQB1 gene were investigated at DNA level for elucidation of the genetic backgrounds of Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. DNA, amplified by polymerase chain reaction, was subjected to allele specific oligonucleotide dot blot analysis, restriction fragment length polymorphism analysis or DNA sequencing. Polymorphism of the TNF...

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Source

Identifiers

PMID: 1676685
DOI: 10.1007/BF00500386

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.PMID 1676685Read ↗

Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitus.Semantic proximity Read ↗

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Genetic susceptibility of childhood type 1 diabetes mellitus in Japan.Semantic proximity Read ↗

The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.Semantic proximity Read ↗

TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes.Semantic proximity Read ↗

Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.Semantic proximity Read ↗

Analysis of tumor necrosis factor-alpha promoter polymorphism in type 1 diabetes: HLA-B and -DRB1 alleles are primarily associated with the disease in Japanese.Semantic proximity Read ↗

An investigation of Japanese subjects maps susceptibility to type 1 (insulin-dependent) diabetes mellitus close to the DQA1 gene.Semantic proximity Read ↗

HLA and non-HLA genetic factors in Japanese IDDM.Semantic proximity Read ↗

Allele-specific gene probing supports the DQ molecule as a determinant of inherited susceptibility to type 1 (insulin-dependent) diabetes mellitus.Semantic proximity Read ↗

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Genetic susceptibility factors of Type 1 diabetes in Asians.Semantic proximity Read ↗

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