HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.

doi:10.1007/BF00500386

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Article

HLA-DQA11 contributes to resistance and A13 confers susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.

Diabetologia - 1 Feb 1991

Yamagata K, Hanafusa T, Nakajima H, Sada M, Amemiya H, Noguchi T, Tanaka T, Kono N, Tarui S

Abstract excerpt

In this study HLA-DQA1 and TNF genes in addition to HLA-DQB1 gene were investigated at DNA level for elucidation of the genetic backgrounds of Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. DNA, amplified by polymerase chain reaction, was subjected to allele specific oligonucl...

Topics

Alleles
Base Sequence
Diabetes Mellitus, Type 1
Disease Susceptibility
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DQ alpha-Chains
Humans
Immunity, Innate
Japan
Molecular Sequence Data
Oligonucleotide Probes
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

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Open in PubMed

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PMID: 1676685
DOI: 10.1007/BF00500386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1676685-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Tumor Necrosis Factor-alpha