Article
HLA-DP and susceptibility to insulin-dependent diabetes mellitus in Japanese.
Tissue antigens - 1 Sept 1991
Yamagata K, Hanafusa T, Nakajima H, Sada M, Amemiya H, Tomita K, Miyagawa J, Noguchi T, Tanaka T, Kono N
Abstract excerpt
Human leukocyte antigen (HLA) genes are candidates for susceptibility genes in insulin-dependent diabetes mellitus (IDDM). Recently, the association of DR and DQ with IDDM has been reported, but the role of HLA-DP genes remains uncertain. To address the question, we analyzed the DPB1 gene of 20 Japanese IDDM patients and 30 control subjects using a combination of polymerase chain reaction (PCR) and restriction...
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