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Article

HLA-DP and susceptibility to insulin-dependent diabetes mellitus in Japanese.

Tissue antigens - 1 Sept 1991

Yamagata K, Hanafusa T, Nakajima H, Sada M, Amemiya H, Tomita K, Miyagawa J, Noguchi T, Tanaka T, Kono N

Abstract excerpt

Human leukocyte antigen (HLA) genes are candidates for susceptibility genes in insulin-dependent diabetes mellitus (IDDM). Recently, the association of DR and DQ with IDDM has been reported, but the role of HLA-DP genes remains uncertain. To address the question, we analyzed the DPB1 gene of 20 Japanese IDDM patients and 30 control subjects using a combination of polymerase chain reaction (PCR) and restriction...

Topics

Alleles
Autoimmune Diseases
Base Sequence
Diabetes Mellitus, Type 1
Disease Susceptibility
Gene Frequency
Genetic Predisposition to Disease
HLA-DP Antigens
Humans
Japan
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 1686679
DOI: 10.1111/j.1399-0039.1991.tb02022.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1686679-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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