Article
Lack of association between an RFLP near the D2 dopamine receptor gene and severe alcoholism.
Biological psychiatry - 1 Feb 1992
Turner E, Ewing J, Shilling P, Smith T L, Irwin M, Schuckit M, Kelsoe J R
Abstract excerpt
Blum et al (1990) have recently examined a restriction fragment length polymorphism (RFLP) detected by TaqI RFLP to the dopamine D2 receptor gene (DRD2) in deceased alcoholics and nonalcoholics, and reported an association between alcoholism and the A1 allele. Subsequent studies, however, by other investigators have failed to confirm this. We have examined the DRD2 TaqI RFLP in 47 living Caucasian males with...
Topics
- Adult
- Alcoholism
- Alleles
- Gene Frequency
- Humans
- Male
- Middle Aged
- Models, Genetic
- Polymorphism, Restriction Fragment Length
- Receptors, Dopamine
- Receptors, Dopamine D2