Article
Lack of allelic association of dopamine D1 and D2 (TaqIA) receptor gene polymorphisms with reduced dopaminergic sensitivity to alcoholism.
Alcoholism, clinical and experimental research - 1 Sept 1996
Heinz A, Sander T, Harms H, Finckh U, Kuhn S, Dufeu P, Dettling M, Gräf K, Rolfs A, Rommelspacher H, Schmidt L G
Abstract excerpt
Our study tested the hypothesis of whether the sensitivity of central dopamine receptors corresponds to the genotypic constitution of DNA-polymorphisms of the dopamine D1 and D2 receptor (DRD1, DRD2) genes and is associated with poor treatment outcome. Therefore, 97 alcohol-dependent patients wer...
Topics
- Adult
- Alcoholism
- Alleles
- Apomorphine
- Chromosome Mapping
- Dopamine
- Female
- Genotype
- Human Growth Hormone
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic
- Receptors, Dopamine D1
- Receptors, Dopamine D2