Article
Genetic predisposition in alcoholism: association of the D2 dopamine receptor TaqI B1 RFLP with severe alcoholics.
Alcohol (Fayetteville, N.Y.) - 1 Jan 2000
Blum K, Noble E P, Sheridan P J, Montgomery A, Ritchie T, Ozkaragoz T, Fitch R J, Wood R, Finley O, Sadlack F
Abstract excerpt
Previous studies have shown an association of the 3' Taq1 A1 allele of the D2 dopamine receptor (DRD2) gene with severe alcoholism. The recent demonstration of a new polymorphism located closer to the regulatory regions of this gene, permits an associational analysis of these 5' Taq1 B alleles with alcoholism and a comparison with the 3' Taq1 A alleles. Restriction fragment length polymorphism methodology was...
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