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Article

The human platelet alloantigens, HPA-5(a+, b-) and HPA-5(a-, b+), are associated with a Glu505/Lys505 polymorphism of glycoprotein Ia (the alpha 2 subunit of VLA-2).

British journal of haematology - 1 Mar 1994

Simsek S, Gallardo D, Ribera A, von dem Borne A E

Abstract excerpt

GP Ia/IIa (also called VLA-2 or alpha 2 beta 1) is the primary receptor for collagen on platelets. The human platelet alloantigens HPA-5a(Brb) and HPA-5b(Bra) have been found to reside on the platelet GP Ia/IIa complex. In order to establish the molecular basis of the HPA-5 system, platelet RNA w...

Topics

Antigens, Human Platelet
Base Sequence
Blood Platelets
Glutamates
Glutamic Acid
Humans
Integrin beta3
Lysine
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Platelet Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Identifiers

PMID: 7913826
DOI: 10.1111/j.1365-2141.1994.tb04808.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7913826-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The human platelet alloantigens, HPA-5(a+, b-) and HPA-5(a-, b+), are associated with a Glu505/Lys505 polymorphism of glycoprotein Ia (the alpha 2 subunit of VLA-2).PMID 7913826Read ↗

NH2-terminal globular domain of human platelet glycoprotein Ib alpha has a methionine 145/threonine145 amino acid polymorphism, which is associated with the HPA-2 (Ko) alloantigens.Semantic proximity Read ↗

Genotyping of the platelet-specific alloantigen HPA-5 (Br(a)/Br(b)) using polymerase chain reaction with sequencespecific primers (PCR-SSP).Semantic proximity Read ↗

Genotyping for human platelet-specific antigens HPA-1, -2, -3, -4 and -5 in the Slovenian population reveals a slightly increased frequency of HPA-1b and HPA-2b as compared to other European populations.Semantic proximity Read ↗

Frequency of platelet‐specific alloantigens in a Danish populationSemantic proximity Read ↗

Human platelet antigen-5 (Br) genotyping by ASPA: allele-specific primer amplification (PCR-SSP)Semantic proximity Read ↗

HPA-5 typing discrepancy reveals an Ile503Leu substitution in platelet GPIa (α2 integrin).Semantic proximity Read ↗

Analysis of platelet glycoprotein Ia (alpha2 integrin) allele frequencies in three North American populations reveals genetic association between nucleotide 807C/T and amino acid 505 Glu/Lys (HPA-5) dimorphisms.Semantic proximity Read ↗

Association of a variable number of tandem repeats (VNTR) in glycoprotein Ib alpha and HPA-2 alloantigens.Semantic proximity Read ↗

Localization of the Br polymorphism on a 144 bp exon of the GPIa gene and its application in platelet DNA typing.Semantic proximity Read ↗

Frequency of human platelet antigens (HPA)-1, -2, -5 and -15 in Brazilian blood donors and establishment of a panel of HPA-typed donors.Semantic proximity Read ↗

HPA-1, 3, 5 genotyping to establish a typed platelet donor panel.Semantic proximity Read ↗

Platelet alloantigens HPA-1, -2, -3, -5 and -6b in Finns.Semantic proximity Read ↗

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