Article
Graduate Student Literature Review: The DRB3 gene of the bovine major histocompatibility complex-Discovery, diversity, and distribution of alleles in commercial breeds of cattle and applications for development of vaccines.
Journal of dairy science - 1 Dec 2024
Galdino Andrade Thales Eduardo, Scavassini Peña Maurício, Fiorotti Jéssica, de Souza Bin Renan, Rodrigues Caetano Alexandre, Connelley Timothy, Ferreira de Miranda Santos Isabel Kinney
Abstract excerpt
The bovine major histocompatibility complex (MHC), also known as the bovine leukocyte antigen (BoLA) complex, is the genomic region that encodes the most important molecules for antigen presentation to initiate immune responses. The first evidence of MHC in bovines pointed to a locus containing 2 antigens, one detected by cytotoxic antiserum (MHC class I) and another studied by mixed lymphocyte culture tests (MHC...
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