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Article

Down-regulation of MHC class I by bovine papillomavirus E5 oncoproteins.

Oncogene - 10 Jan 2002

Ashrafi G Hossein, Tsirimonaki Emmanouella, Marchetti Barbara, O'Brien Philippa M, Sibbet Gary J, Andrew Linda, Campo M Saveria

Abstract excerpt

The papillomavirus E5 protein is localized in the endoplasmic reticulum (ER) and Golgi apparatus (GA) of the host cell. Transformed bovine fibroblasts expressing bovine papillomavirus (BPV) E5 are highly vacuolated and have a much enlarged, distorted and fragmented GA. Major histocompatibility complex class I (MHC I) is processed and transported to the cell surface through the GA. Given the cellular localization...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Transformation, Viral

Share to Genes, MHC Class I

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Share to Oncogene Proteins, Viral

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Source

Identifiers

PMID: 11803468
DOI: 10.1038/sj.onc.1205008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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