Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

Molecular and cellular biology - 1 Oct 1992

Kingsley C, Winoto A

Abstract excerpt

Analysis of a T-cell antigen receptor (TCR) alpha promoter from a variable gene segment (V) revealed a critical GT box element which is also found in upstream regions of several V alpha genes, TCR enhancer, and regulatory elements of other genes. This element is necessary for TCR gene expression and binds several proteins. These GT box-binding proteins were identified as members of a novel Sp1 multigene family....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Molecular Sequence Data

Share to Mutation

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1341900
DOI: 10.1128/mcb.12.10.4251-4261.1992
PMCID: PMC360348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.PMID 1341900Read ↗

Transcription Factor Sp1 in the Expression of Genes Encoding Components of Mapk, JAK/STAT, and PI3K/Akt Signaling PathwaysSemantic proximity Read ↗

Different members of the Sp1 multigene family exert opposite transcritional regulation of the long terminal repeat of HIV-1Semantic proximity Read ↗

Sp1 and Sp3 transactivate the RET proto-oncogene promoter.Semantic proximity Read ↗

Sp3 represses gene expression via the titration of promoter-specific transcription factors.Semantic proximity Read ↗

Dual regulation of ets-activated gene expression by SP1.Semantic proximity Read ↗

O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions.Semantic proximity Read ↗

Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB.Semantic proximity Read ↗

Multiple Sp1 sites efficiently drive transcription of the TATA-less promoter of the human glypican 3 (GPC3) gene.Semantic proximity Read ↗

Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators.Semantic proximity Read ↗

Thyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-α in lung epithelial cells.Semantic proximity Read ↗

A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter.Semantic proximity Read ↗

The role of viral enhancer "core" motif-related sequences in regulating T cell receptor-gamma and -delta gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.